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Simona Sestito Selected Research

3-Phosphoinositide-Dependent Protein Kinases

10/2019Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation.
5/2019Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer.
1/2019A patent update on PDK1 inhibitors (2015-present).

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Simona Sestito Research Topics

Disease

8Neurodegenerative Diseases (Neurodegenerative Disease)
05/2022 - 01/2017
5Neoplasms (Cancer)
06/2022 - 01/2019
5Fabry Disease (Fabry's Disease)
01/2018 - 05/2010
4Alzheimer Disease (Alzheimer's Disease)
01/2019 - 01/2017
2Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
06/2022 - 01/2021
2Epilepsy (Aura)
12/2021 - 01/2017
2Adenocarcinoma
04/2020 - 05/2019
2Metabolic Syndrome (Dysmetabolic Syndrome X)
03/2020 - 02/2020
2Pancreatic Neoplasms (Pancreatic Cancer)
10/2019 - 05/2019
2Glioblastoma (Glioblastoma Multiforme)
01/2017 - 11/2015
1Retinitis Pigmentosa (Pigmentary Retinopathy)
05/2022
1Cone-Rod Dystrophies
05/2022
1Blindness (Hysterical Blindness)
05/2022
1Constipation
03/2022
1Food Hypersensitivity (Food Allergy)
03/2022
1Mucopolysaccharidoses
01/2022
1Ewing Sarcoma (Sarcoma, Ewing)
12/2021
1Phenylketonurias (Phenylketonuria)
11/2021
1Partial Epilepsies (Epilepsy, Partial)
03/2021
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2021
1Rare Diseases (Rare Disease)
01/2021
1Birth Weight (Birth Weights)
12/2020
1Thyroid Dysgenesis (Thyroid Agenesis)
12/2020
1Asthma (Bronchial Asthma)
09/2020
1Mouth Neoplasms (Oral Cancer)
09/2020
1Cardiotoxicity
05/2020
1Osteosarcoma (Osteogenic Sarcoma)
04/2020
1Obesity
02/2020
1Heart Failure
02/2020
1Cardiac Arrhythmias (Arrythmia)
02/2020
1Tachycardia (Tachyarrhythmias)
02/2020
1Eczema
01/2020
1Pneumonia (Pneumonitis)
01/2020
1COVID-19
01/2020
1Atopic Dermatitis (Atopic Eczema)
01/2020
1Hypertension (High Blood Pressure)
01/2020
1Hypersensitivity (Allergy)
01/2020
1Dysbiosis
01/2020
1Breast Neoplasms (Breast Cancer)
10/2019

Drug/Important Bio-Agent (IBA)

7EnzymesIBA
04/2020 - 05/2010
5Proteins (Proteins, Gene)FDA Link
11/2021 - 01/2017
4Phosphotransferases (Kinase)IBA
12/2021 - 08/2016
4GalactosidasesIBA
01/2018 - 01/2013
3GlycosaminoglycansIBA
01/2022 - 01/2013
3Phosphatidylinositols (Phosphatidylinositol)IBA
12/2021 - 01/2017
3Protein Isoforms (Isoforms)IBA
05/2020 - 05/2019
33-Phosphoinositide-Dependent Protein KinasesIBA
10/2019 - 01/2019
3LigandsIBA
07/2019 - 01/2017
2AntigensIBA
06/2022 - 01/2021
2Reactive Oxygen Species (Oxygen Radicals)IBA
05/2022 - 01/2017
2Cytochrome P-450 CYP1A2 (CYP1A2)IBA
12/2021 - 04/2020
2Cytochrome P-450 CYP2D6 (CYP2D6)IBA
12/2021 - 04/2020
2Cytochrome P-450 CYP2C9IBA
12/2021 - 04/2020
2Cytochrome P-450 CYP2C19IBA
12/2021 - 04/2020
2Pharmaceutical PreparationsIBA
12/2021 - 01/2017
2sperm ganglioside 2IBA
02/2020 - 01/2017
2Aurora Kinase AIBA
10/2019 - 01/2017
2Antineoplastic Agents (Antineoplastics)IBA
10/2019 - 12/2013
2Rivastigmine (Exelon)FDA LinkGeneric
12/2017 - 01/2017
22-oxindole (oxindole)IBA
11/2015 - 12/2013
1CytokinesIBA
06/2022
1Glycoproteins (Glycoprotein)IBA
06/2022
1Retinaldehyde (Retinal)IBA
05/2022
1AllergensIBA
03/2022
1Cytidine Monophosphate (CMP)IBA
03/2022
1Milk Proteins (Milk Protein)IBA
03/2022
1HydrolasesIBA
01/2022
1Phenylalanine (L-Phenylalanine)FDA Link
11/2021
1MicronutrientsIBA
11/2021
1Neutral Amino AcidsIBA
11/2021
1Biological ProductsIBA
10/2021
1Anticonvulsants (Antiepileptic Drugs)IBA
03/2021
1AntioxidantsIBA
02/2021
1Monoclonal AntibodiesIBA
01/2021
1Thyroxine (Levothyroxine)FDA LinkGeneric
12/2020
1Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
12/2020
1Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA
05/2020
1Aurora Kinase BIBA
04/2020
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
04/2020
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2020
1Cytochrome P-450 CYP3AIBA
04/2020
1Trace amine-associated receptor 1IBA
03/2020
13-iodothyronamineIBA
03/2020
1CholesterolIBA
02/2020
1Triglycerides (Triacylglycerol)IBA
02/2020
1Triiodothyronine (Liothyronine)FDA LinkGeneric
02/2020
1Angiotensin Receptor AntagonistsIBA
01/2020
1Antihypertensive Agents (Antihypertensives)IBA
01/2020
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2020
1Thyroid Hormone Receptors beta (TR beta)IBA
01/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1PrebioticsIBA
01/2020
1serum-glucocorticoid regulated kinaseIBA
05/2019
1ProdrugsIBA
01/2019

Therapy/Procedure

5Therapeutics
12/2021 - 01/2017
2Enzyme Replacement Therapy
12/2017 - 01/2017
1Immunotherapy
06/2022
1Protein-Restricted Diet (Diet, Protein Restricted)
11/2021
1Oral Hygiene (Dental Hygiene)
09/2020
1Investigational Therapies (Experimental Therapy)
07/2019